Rapid technological progress at the beginning of the third decade of the 21th century entails new approaches to structuring the segments of cultural industries and their produce. The article substantiates the introduction of such concepts as “artistic industries”, “cultural industries”, and “creative industries” in Russia and their merging into a cluster system with subsequent transformation into a meta- and ecosystem of creative production of ideas, goods and services. The article reveals the influence of IT-technologies on the cultural and creative sector of digital economy and the impact of creative industries on the sociocultural paradigm of the society entering a new digital reality.The author justifies the immersion of our contemporary in a symbiotic human-machine relationship which means the introduction of artificial intelligence (AI), the Internet of Things (IoT), and VR technologies (VR). Their increasing appropriation is changing the landscape of the Internet space as a prototype of a new networked information-digital structure. Some scholars rate these processes as a “Great Anthropological Transition”, since our contemporary is connected with four Umvelts: the Techno-world of machines, gadgets and robots; the Neuro-world of virtual reality; the Myth-world of culture and history; the Net-world of networks and collective unconscious (crowd-sourcing and crowd-funding). Synergy researchers propose to minimize the problem of mastering intellectual technologies, i. e. to elaborate an array of “value-oriented tools in the socio-techno-sphere as a complex open system”, to draw up roadmaps for social development. A symbolic role is also assigned to creative industries, which are now structurally forming in Russia as a humanitarian segment of digital economy in the form of clusters and meta-systems in megacities and regions.